Chronic fatigue refers to persistent, overwhelming tiredness that does not improve with rest and significantly interferes with daily activities. It may be a symptom of various underlying conditions such as anemia, thyroid disorders, sleep disturbances, depression, autoimmune diseases, or chronic infections, and in some cases may be associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a complex disorder characterized by profound fatigue, post-exertional malaise, cognitive difficulties, and unrefreshing sleep. Individuals may also experience muscle or joint pain, headaches, and difficulty concentrating. Because chronic fatigue can have multiple potential causes, thorough medical evaluation is important to identify contributing factors. Management focuses on addressing underlying conditions, improving sleep and stress management, pacing activities, and supporting overall physical and mental health.
