Gangrene is a serious medical condition characterized by the death of body tissue due to a loss of blood supply, severe infection, or traumatic injury. It most commonly affects the extremities such as the toes, fingers, and feet but can also involve internal organs. Types include dry gangrene, often related to poor circulation from conditions like diabetes or peripheral artery disease, and wet gangrene, which involves bacterial infection and can spread rapidly. Symptoms may include discoloration (black, blue, or green skin), swelling, foul-smelling discharge, severe pain followed by numbness, and signs of systemic illness in advanced cases. Gangrene is a medical emergency requiring prompt treatment, which may include antibiotics, surgical removal of dead tissue, restoration of blood flow, or in severe cases, amputation to prevent life-threatening complications.